Title: Effect of antiretroviral therapy to hepatitis Bcirrhosis
Abstract: Objective To investigate the clinical therapeutic effect of Nucleoside drugs on decompensated cirrhosis patients following chronic hepatitis B. Methods 96 decompensated cirrhosis patients were randomly divided into four groups,all the groups were given conventional treatment while the group A were given lamivudine 100 mg/day,group B were given adefovir 10 mg/day,group C were given entecavir 0.5 mg/day,with treatment for 48 weeks.The control group were given conservative treatment only.Then to observe the clinical symptoms,body signs of all the patients,the changes of the liver functions,Prothrombin time activity(PTA),HBV DNA level and HBeAg negative,HBeAg/HBeAb conversion situation. Results After Nucleoside antiviral treatments for 48 weeks,no patients died in the study groups. Decompensated cirrhosis patients were significantly improved in clinical symptoms ,body signs,liver functions,PTA ,with decreased HBV DNA level(P0.05); the rates of HBeAg negative in these three groups were 20%,8% and 23%,there was significant differences for these three groups(PA/B0.05,PC/B0.05,PA/C0.05),the rates of HBV-DNA negative for these three groups ware 48%,28% and 68.2%,differences of the three groups were also significant(PA/B0.05,PC/B0.05,PA/C0.05),the therapeutic efficacy was worst for the control group,3 cases died,there was an obvious therapeutic efficacy difference between anti-virus treatment groups and control group(P0.01)。Conclusion Decompensated liver cirrhosis patients of Hepatitis B should receive antiretroviral treatment. Lamivudine and Entecavir can be chosen first for the treatment. In order to prevent the viral mutation induced by Lamivudine,use adefovir to continue the antivirus treatment when patients conditions improved.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Cited By Count: 1
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