Title: The Value of MAGE-3 mRNA Expression in Pleural Effusion in Differential Diagnosis of Benign and Malignant Pleural Effusion
Abstract:Objective This research was to detect whether the differential expression profile of the MAGE-3 mRNA occurred in pleural effusion,and to explore the feasibility of MAGE-3 gene detection as a diagnosti...Objective This research was to detect whether the differential expression profile of the MAGE-3 mRNA occurred in pleural effusion,and to explore the feasibility of MAGE-3 gene detection as a diagnostic marker for benign and malignant pleural effusion.Methods MAGE-3 mRNA in pleural effusion was detected by nested RT-polymerase chain reaction(nRT-PCR) in 35 cases of patients(25 malignants and 10 benigns) complicating pleural effusion.Results No MAGE-3 expression in pleural effusion of 10 patients complicating benign pleural effusion.As opposed to the benign controls,out of the 25 patients complicating malignant pleural effusion,14 ases of MAGE-3 expression amplification strap were observed in pleural effusion and the rate of positive,sensitivity,specificity,accuracy were 56.00%,56.00%,100.00%,68.57% to part.Conclusion To detect MAGE-3 mRNA of pleural effusion might be a valuable diagnostic indicator for benign and malignant pleural effusion.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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