Title: Study of entecavir in treating chronic severe hepatitis B patients
Abstract: OBJECTIVE To study the effect and safety of antiviral treatment for chronic hepatitis B Patients with entecavir.METHODS 56 patients which was the early/middle severe hepatitis B patients were 1:1 to receive either ETV(0.5 mg,qd) as treatment group or Comprehensive treatment as the control group.Measurements of liver function(TB、ALT、AST、ALB and PT),Serum Markers of Hepatitis B(HBsAg,HBsAb,HBeAg,HBeAb and HBcAb),and serum HBVDNA by PCR assay were wnducted.Statistic analyses for the clinical cure rate and improvement proportion were made.RESULTS The effective function was reducing serum HBV DNA levels.The difference of statistic analysis was observed about the liver function improvement at week 3.But about the clinical cure rate and improvement proportion,no difference at week 6.CONCLUSION The liver function could be improved with antiviral treatment of entecavir.At first 1-2 weeks,the effect is no difference between the two groups.But at week 3,week 4,it turns to obviously statistic difference and having the treatment significance.The effect of antiviral treatment with entecavir is measurably in chronic severe hepatitis B patient.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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