Title: Pharmacokinetics and Relative Bioavailability of Azithromycin Tablets
Abstract: The concentration time process of azithromycin tablets in 20 healthy volunteers was observed. The plasma concentrations of azithromycin were determined by microbiological method. The pharmacokinetic parameters for the single oral dose of tested tablets were C max 580.75±156.62 μg/L, T max 1.60±0.68 h, t 1/2 36.60±3.74 h, MRT 40.30±5.43 h and AUC 0→144 4491.03±979.05 μg·h·L -1 . The main pharmacokinetic parameters were not significantly different between the tested and reference tablets, except T max (2.45±0.69 h for the latter). The relative bioavalability of tested tablets was 97.14±11.28%.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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