Title: EFFECT OF CALCIUM LEUCOVORIN ON MOUSE L615 MINIMAL RESIDUAL LEUKEMIA
Abstract: This study was conducted to establish a L615 mouse minimal residual leukemia model and examine the effect of calcium leucovorin (LV) on minimal residual leukemia (MRL). A log-linear correlation was observed between the member of L615 leukemic cells inoculated and the mean survival time of the recipient mice. Though the survival time of 615 mice inoculated with L615 leukemic cells was prolonged by treatment with a single dose of cytarabine (Ara-C, 3g / m2) intraperitoneally, the Ara-C treated mice all died of relapse. At 48 hour after Ara-C treatment, the residual leukemic cells in the mice were much fewer and perhaps in a state of dormant. Thus, the mice could be used as L615 minimal residual leukemia model.
The mean survival time of MRL mice treated with LV(50-200mg / m2 / d, i. p. qd × 5) (17.9± 2.19-13.31 1.35 days) was significantly shorter than that of MRL mice without LV administration (24.7± 2.55 days). Pathologic examinations indicated that LV administration induced aplasia during recovery from chemotherapy was able to stimulate the proliferation of splenic nodules in MRL mice, in the meantime, it also accelerated the leukemic infiltration of the. spleen. These results suggest that LV administration failed to show any anti-neoplastic effect but instead accelerated the relapse in MRL mice.
Publication Year: 1995
Publication Date: 1995-01-01
Language: en
Type: article
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