Title: Mycobacterium ulcerans infection (Buruli ulcer) First report of six cases in China with literature review.
Abstract: Objective To report the six Mycobacterium ulcerans infections (Buruli ulcer) in China which is the third most common mycobacterial infection in West Africa after tuberculosis and leprosy, with literterature review and to provide sciertific information for diagnosis and treal ment of the disease. Methods Six patients with chronic ulcers in lower or upper extremities were diagnosed clinically, and confirmed either by histopathologically, or by PCR or both, then managed by surgical approach of the six caoes. Results One case was male, one male and five were females, with an averaged age of 69 years (47 - 83 years) . The clinical manifestations of the patients were deep, indolent, chronic ulcer with undermined margin in their legs in five cases, and in the legs and left finger in one case. Left side outnumbered right one. The diameter of the ulcer was 2.5 -6.5 cm, averaged 3.2 cm. The microscopic findings in the lesion showed extra - cellular anti - fast bacilli and ghost cells. Anti - tuberculosis drugs and antibiotics have no effectiveness to the patients. Six cases had a satisfactory result except one whe had recurrent ulcer after surgical intervention. Conclusion Chronic unusual skin lesions. occurred in this country should consider Mycobacterium ulcerans infection Surgery remains the mainstay of potentially curative treatment.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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