Title: Expression and clinical pathological significance of VEGF,KAI-1,c-kit in triple-negative breast cancer
Abstract: Objective To explore the expression and clinical pathological significance of VEGF,KAI-1,c-kit in triple-negative breast cancer.Methods PV-9000 immunohistochemistry technique was applied to detect the expression of VEGF,KAI-1,c-kit in 85 triple-negative breast cancer cases.Results (1) The positive rate of VEGF was 76.47%(65/85) in TNBC.The expression of VEGF was associated with tumor size(P0.05).(2) The positive rate of KAI-1 in TNBC was 42.35%(36/85).The expression of KAI-1 was associated with size,metastasis of lymph nodes and recurrence(P0.05).(3) The positive rate of c-kit in TNBC was 44.70%(38/85).The expression of c-kit was associated with size,metastasis of lymph nodes and clinical stage(P0.05).Conclusion The positive expression of VEGF,the negative expression of KAI-1,the negative expression of c-kit may contribute to the growth of triple-negative breast cancer.KAI-1 and c-kit may play important roles in triple-negative breast cancer metastasis and might serve as a marker to predict metastasis.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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