Title: Effect of dexmedetomidine on general anesthesia maintenance and recovery on children receiving cardiac catheterization
Abstract: Objective To investigate the effect of dexmedetomidine on general anesthesia maintenance and recovery on children receiving cardiac catheterization. Methods Eighty- four children undergoing cardiac catheterization( 1- 11 years old) were randomly divided into two groups: 41 cases in dexmedetomidine combined with sevoflurane group( DS group) cases and 43 cases in sevoflurane group( S group). All of the children were injected with katemine 1 mg·kg- 1. Then dexmedetomidine was injected with an initial loading dose( 1 μg · kg- 1) for 10 minutes followed by a continuous infusion( 2 μg · kg- 1·h- 1) in DS group. Normal saline was injected in S group. The depth of anesthesia in all patients were monitored by bispectral index( BIS),which were maintained between 55 and 65 through adjusting sevoflurane inhalation.During operation,the data of heart rate( HR),mean arterial pressure( MAP),respiration rate( RR),BIS,pressure of end- tidal carbon dioxide( PetCO2) and concentration of end- tidal sevoflurane( CetSev)of children at the time to enter the operating room( T0),the time point of laryngeal mask( LMA) insertion( T1),20 min after LMA( T2),thetime point of LMA removed( T3) were recorded,as well as the time of operation and recovery,complication including supplemental sedatives,and the rate of respiratory depression,nausea and vomit. Results The data of HR in DS group were significantly lower at T1,T2 and T3compared with S group( P 0. 01). The exhaled sevoflurane concentration of DS group was significantly lower at T2 and T3than S group( P 0. 01). The recovery time of DS group was significantly longer than those of S group( P 0. 01). The cases requiring supplemental sedatives in DS group were less than that in S group( 12 vs 37,P 0. 01). Conclusion Dexmedetomidine is advantageous on general anesthesia maintenance and recovery in children receiving cardiac catheterization.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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