Title: Study on One-Pot Synthesis of 2-Ynyl-Benzofuran with Palladium as Catalyst
Abstract: Four 2-ynyl-benzofurans were synthesized by the reaction of 2-ethynylaniline and E-1,2-diiodoalkenes in the presence of palladium (II) acetate and copper (I) iodide as the catalysts via a one-pot reaction in a triethylamine-tetrahydrofuran medium. The reaction at room temperature for 15 h and then at 100 ℃ for the remaining time gave the desired 2-ynyl-benzofurans in moderate yields under mild conditions. The structures of the product were characterized and confirmed by MS and NMR spectrum.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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