Title: The Clinical Significance of Axillary Sentinel Lymph Node Biopsy in Breast Cancer Patients after Neoadjuvant Chemotherapy
Abstract:Objective To investigate feasibility of sentinel lymph node biopsy for breast cancer patients after neoadjuvant chemotherapy.Methods Sixty seven breast cancer patients underwent sentinel lymph node bi...Objective To investigate feasibility of sentinel lymph node biopsy for breast cancer patients after neoadjuvant chemotherapy.Methods Sixty seven breast cancer patients underwent sentinel lymph node biopsy(SLNB) using 99Tc combining methylene blue dye as tracer and axillary lymph node dissection(ALND) were retrospectively reviewed.Thirty one of the patients staging ⅡB and Ⅲhad SLNB and ALND after 2~3 circles neoadjuvant chemotherapy,another 26 patients staging Ⅰand Ⅱ had directly SLNB and ALND without neoadjuvant chemotherapy.Results The number of axillary lymph nodes,sentinel lymph nodes,identification rate and false negative rate in breast cancer patients with neoadjuvant chemotherapy were not significantly different from early breast cancer patients without neoadjuvant chemotherapy(all P0.05).In additional,in neoadjuvant chemotherapy group,the identification rate in the cases of N2 stage were lower than in N0~1 stage significantly(P=0.012).Conclusion The SLNB can accurately predict lymph node status of axillary lymph node in patients with neoadjuvant chemotherapy.Clinical N stage is a predictor to the identification rate of SLND in the patents.Read More
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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