Title: Expressions of MMP-2 and TIMP-2 Protein in Cervical Adenocarcinoma and the Relationship between the Expression and Metastasis
Abstract: Objective To investigate the expressions of matrix metalloproteinase 2(MMP-2) and tissue inhibitor of matrix metalloproteinase 2(TIMP-2) protein in the tissue of cervical adenocarcinoma and its correlation the metastasis of cancer and to reveal the mechanism of infiltration in this cancer.Methods The expressions of MMP-2 and TIMP-2 protein were observed by immunohistochemistry(IHC)technique in 10 cases of cervical chronic inflammation and 63 cervical adenocarcinoma.Results No positive expressions of MMP-2 and TIMP-2 in cervical chronic inflammation,while the positive rate was73.0% and 82.5% respectively in cervical adenocarcinoma.The positive rate of MMP-2 protein expression in cervical adenoferous carcinoma and papillary adenocarcinoma was 81.8% and 58.3% respectively.MMP-2 and TIMP-2 protein′s expressions had no relevance with clinical stage( P 0.05 ).In this study there was a very significant correlation between the expressions of MMP-2 and TIMP-2 protein( P 0.01) and the expression of MMP-2 was positively correlated to metastasis of cancer( P 0.05).Conclusion The MMP-2 protein may act as an index to indicate the process of the infiltration and metastasis in cervical adenocarcinoma.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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