Title: Galangin Attenuates Cognitive Impairment in Senescent Mice
Abstract: Objective To investigate the effect of galangin(GL) on cognitive impairment in the senescent mice induced by D-galactose(D-gal).Methods D-gal was subcutaneously injected to establish a senescent mice model.The Morris water maze test and step-down avoidance one were performed to study the learning and memory abilities of mice.The activities of superoxide dismutase(SOD),glutathione peroxidase(GPx),catalase(CAT) and content of malondialdehyde(MDA) in mice hippocampus were detected by biochemical examination.Results The mice treated with D-gal generated significant cognitive deficiency.Administration of GL to D-gal treated mice ameliorated cognitive impairment in the hippocampus.Biochemical examination revealed that GL attenuated the decreased activities of SOD,GPx,CAT and reduced MDA levels in the hippocampus of D-gal-treated mice.Conclusion Galangin possesses anti-oxidative effect by improving the cognitive function,and increasing activities of SOD,GPx,CAT and lowering MDA of the senescent mice induced by D-gal.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 3
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