Title: The Relationship between the Level of Serum Estrogen (E_2) and Pregnancy in vitro fertilization-embryo transfer cycle
Abstract: Objective To investigate the relationship between estrogen levels of controlled ovarian hyperstimulation(COH) cycle and in vitro fertilization-embryo transfer(IVF-ET) outcome.Methods 200 cases who due to tubal factors and(or) male factor infertility underwent COH,tested serum estrogen(E2) levels on the day of injecting human chorionic gonadotropin(hCG) and ET on the 5th day.According to changes in E2after the injection of HCG,they were divided into increased group(0) and decreased group(0).In the decreased group,to calculate the ratio of the minus of serum E2 levels on the day of injecting hCG,or E2% =(HCG day E2-transplant 5th day E2) / HCG day E2 × 100.They were divide into 6 groups according to the percentage of reduced E2: group 1 E2decreased of 20%,group 2 E2decreased of 20%~29%,group 3 E2decreased of 30%~39%,groups 4 E2decreased of 40%~49%,groups 5 E2 declined from 50% to 59%,group 6 E2 decreased ≥ 60%.Results There were 86 cases of clinical pregnancy(43%),patient′s age,hCG day E2levels,number of retrieved oocytes,fertilization rate,ET on the level of E2 were not different significantly between the pregnancy group and non-pregnant group.In the dropped six groups: ET on the 5th day,E2of the first group,the sixth group were different compared with the other four groups;HCG day,E2of the sixth group were different compared with the other five groups.Conclusion Combination of published literature,in IVF cycles,the rapid decline in E2of hCG day and ET on the 5th day can predict the outcome of pregnancy,the rapid decline in estrogen levels might impair endometrial receptivity,and the suitable complement to the luteal phase estrogen may be benefit to pregnancy outcome.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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