Title: Areas in the rat brain involved in blood pressure modulation——functional and morphological studies of FOS protein
Abstract: To observe the areas in the central nervous system of rat in which the cardiovascular functions are adjusted reflexly, animal models of hypotention in rats were induced by injecting sodium nitroprusside into the vein. And the distributions of FOS positive neurons in the brain were studied immunohistochemically. Hypotention induced a significant increase in FOS immunoreactivity in the medullary visceral zone, parabrachial nucleus, locus coeruleus, A5 area, ventrolateral area of periaqueductal gray. FOS positive neurons expressed highly in the paraventricular nucleus, supraoptic nucleus, suprachiasmatic nucleus of hypothalamus too. Dense FOS immunoreactive staining were also seen in the paraventricular nucleus of thalamus, lateral habenular nucleus, central nucleus of amygdala, bed nucleus of stria terminalis, lateral septal nucleus, frontal cortex, cingulate gyrus and prepiriform cortex. The results show that several blood pressure modulating areas exist from cerebral cortex to medulla, and they connect each other forming a complicated central modulating network.[
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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