Title: Protection of Longyanshen Polysaccharide on CCl 4 -induced Damage of Primary Cultured Hepatocytes in Rats
Abstract: OBJECTIVE:To study the protection of Longyanshen polysaccharide(LYS)on the damage of primary cul-tured hepatocytes in rats and its mechanism.METHODS:The damage of primary cultured hepatocytes in rats was induced with CCl 4 in vitro,the levels of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in the cultured super-natant and the contents of malondialdehyde(MDA)and glutathione(GSH)in hepatocytes were determined,cytoactive was detected by MTT method.RESULTS:Compared with model group,the AST and ALT levels and MDA content in hepatocytes in LYS group were significantly decreased,the survival rates of hepatocytes and GSH content were increased.CONCLUSIONS:LYS shows a direct protective action on the damage of the primary cultured hepatocytes in rats,which is possibly associated with its anti-oxidative activity.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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