Title: Effects of repetitive transcranial magnetic stimulation on tyrosine hydroxylase positive staining in rat globus pallibus and substantia nigra
Abstract:AIM To observe the effects of repetitive transcranial magnetic stimulation (rTMS) on tyrosine hydroxylase (TH) positive staining in rat globus pallibus and substantia nigra. METHODS Animals were treat...AIM To observe the effects of repetitive transcranial magnetic stimulation (rTMS) on tyrosine hydroxylase (TH) positive staining in rat globus pallibus and substantia nigra. METHODS Animals were treated with repetitive stimulation of 1 Hz, 100 mT electromagnetic field 10 minutes per day for 14 days, and then TH positive neurons and fibers in global pallidus (GP)and substantia nigra (SN) were detected immunohistochemically. RESULTS Compared with that in control group, high TH positive fibers were induced in the GP of experimental rats, especially in the external part of GP (GPe) and ventral globus pallidus (VGP). No significant difference of the numbers of TH positive cells in substantia nigra pars compacta (SNC) and pars reticulata (SNR) in both groups, but TH positive fibers in SNR and lateral substantia nigra (SNL) of rTMS group animals increased than that in sham stimulation group. CONCLUSION Dopamine levels in globus pallidus especially external pallidus and substantia nigra pars reticulata that are main output nucleus of basal ganglia could be modulated by rTMS. We presume that it may play some role in treating neurological disorders such as Parkinson's disease.Read More
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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