Title: Effects of fentanyl on the anesthetic effect and dose-effect relationship of ropivacaine in lower epidural anesthesia
Abstract: Objective To investigate the effects of fentanyl on the anesthetic effect and dose-effect relationship of ropivacaine for epidural anesthesia.Methods Sixty patients with ASA physical statusⅠ~Ⅱscheduled for partial removal of vertebral disc were random- ly divided into 3 groups(A,B,C),20 patients in each group.Epidural puncture was performed at T_(12)/L_1intervertebral space,and the catheter was inserted 3 cm into the epidural space toward candae in all patients.The local anesthetic compounding regimen was 0. 5% ropivacaine,0.5% ropivacaine + fentany12mg/L,or 0.5% ropivacaine + fentany14 mg/L for group A,B,C,respectively.The level of sensory anesthesia and degree of motor block were assessed by pinprick and modified Bromage scale,respectively.The volume of local anesthetic administrated,anesthesia duration,and side effects were also recorded.The ED_(50)and ED_(95)in each group were ob- tained by probit analysis.Results The anesthetic effect was satisfactory in 58 of 60 patients.The ED_(50)(27.94 mg±8.4 mg)and ED_(95) (56.48 mg±9.92 mg)of ropivacaine of group C were significantly less than those of group A (ED_(50)37.56 mg±8.5 mg and ED_(95) 75.94 mg±21.4 mg,P0.05).The modified Bromage score in group C (0.45±0.5)was significantly lower than that in group A (1.85±0.7)and group B (1.65±0.7),P0.05.The duration of anesthesia for group A,B,C were 225 min±23 min, 340 min±47 min,and 410 min±36min,respectively.There was no significant difference in the incidence of side effects and com- plications among the 3 groups.Conclusion In epidural anesthesia,fentanyl could improve the anesthetic effects of ropivacaine,prolong the anesthetic duration and decrease ropivacaine dosage,diminish motor blockade,especially in group C.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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