Title: Safety Investigation on Lyophilized Live Attenuated Measles-Mumps-Rubella Combined Vaccine
Abstract: Objective To study the safety of live attenuated measles-mumps-rubella combined vaccine(MMR) produced by Shanghai Biological Product Institute,and to provide scientific evidence for the use.Methods Children aged 7 to 15 years and 8 to 18 months were selected to be vaccinated with Shanghai MMR vaccine.Other groups of children with similar characters were vaccinated with measles vaccine,mumps vaccine,rubella vaccine or imported MMR vaccine as controls.The study was divided into three phases.Results During the phaseⅠ,among 11 children of 7 to 15 years who vaccinated with Shanghai MMR vaccine,27.3% of the children had the local side effect but with no other signs observed.Among 26 children of 8 to 11 months,11.5% of the children had fever,15.4% had signs of rash and 3.8% had high fever.Totally 1 188 children aged 8 to 18 months were observed during the phaseⅡand the phase Ⅲ.In the experiment group,11.76% of the children had fever,3.64% had signs of rash,and local side effect rate and other side effect rate was 0.44%,0.33% respectively.There was significant difference in fever rate between experiment group with Shanghai MMR vaccine and control groups with mump vaccine and rubella vaccine.Conclusion The Shanghai MMR vaccine is as safe as the measles vaccine,mump vaccine,rubella vaccine and imported MMR vaccine which have been used.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot