Title: The clinical application of ganciclovir in congenital cytomegalovirus,infections
Abstract: Objective To investigate the therapeutic effect of ganciclovir on congenital cytomegalovirus (CMV) infections and relative factors.Methods 30 cases of congenital CMV infections were divided into symptomatic (n=14) and asymptomatic (n=16 groups.Both groups were treated with ganciclovir according to the routine regime.The results of quantitive CMV-PCR were applied to evaluate the therapeutic effect.Results After treatment,the negative rate was 17/30 (56^8%) in Induction phase and 26/30 (86^7%) in Maintenance phase.The negative rate in Induction phase of infants with CMV-DNA ≤10+4 copy/ml was higher than those with CMV-DNA10+4 copy/ml (P0^05).The negative rate in Induction phase of asymptomatic infants was also higher than symptomatic ones (P=0^007) The rate in Maintenance phase were insignificantly different.Conclusion It was safe and effective to treat congenital CMV infections with ganciclovir and its course was relevant to the number of CMV-DNA and the type of infection.It is suggested that all of infants with congenital CMV infections should be early given intervening therapy.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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