Title: Optimization of Preparation Technology of β-Cyclodextrin Inclusion Complexes for Volatile Oil in Guanxinkang Capsule
Abstract: Objective:To grope preparation technology of β-cyclodextrin(β-CD) inclusion compound of volatile oil in Guanxinkang capsule,in order to improve stability of volatile oil.Method:Inclusion complexes was prepared by saturated aqueous solution ultrasonic method,with inclusion rate of volatile oil,inclusion oil content and inclusion yield as comprehensive evaluation index,influence of ratio of β-CD and volatile oil,inclusion temperature and ultrasonic time on inclusion technology was investigated by central composite design,test data was fitted by multi-linear regression and binomial equation,inclusion technology conditions were optimized by response surface method,and to predictive analysis.Result:Optimum inclusion process conditions were as follows:ratio of β-CD and volatile oil of 7:1,inclusion temperature at 45 ℃ and ultrasonic time of 40 min,deviation between observed and predicted values was less than 3%.Conclusion:Volatile oil was powdered and its stability had been increased after being included by β-CD.This optimized inclusion process was simple with high predictability,it could provide test basis for industrial production of Guanxinkang capsule.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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