Title: Study on the expression of p53、 p16 protein and PCNA in oral precancerous lesion and oral squamous cell carcinoma
Abstract: Objective: To investigate the relationship of expression between p53、p16 protein and PCNA and their significance during the development and progression of oral precancerous lesion, and squamous cell carcinoma. Methods: Expression of p53、p16 protein and PCNA were detected in oral lichen planus (OLP) 20 cases, oral leukoplakia (OL) 20 cases and oral squamous cell carcinoma (OSCC) 20 cases by immunohistochemical techniques. Results: (1) The positive rate of p53 protein was higher in OSCC (90.0%) than in OL (10.0%) and OLP (0.0%) (P0.005), (2) The positve rate of p16 protein was lower in OSCC (35.0%) than in OL (70.0%) and OLP (90.0%) (P0.005). (3) The positive rate of PCNA was higher in OSCC (90.0%) than in OL(10.0%) and OLP (0.0%) (P0.005) . Conclusion: p53 gene mutation resulting in over-expresion of p53 protein, the low-expression of p16 protein and over-expression of PCMA may play important roles in oral squamous cell carcinoma development and progression.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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Cited By Count: 2
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