Title: The correlation between CT perfusion parameters and microvessel density in hepatocellular carcinoma
Abstract: Objective To explore the correlation of CT perfusion data of hepatocellular carcinoma (HCC) with microvessel density (MVD). Methods Eighteen cases of HCC proved by pathology and examined by perfusion CT and CD34 staining were studied. After plain CT scan of the whole liver, a single slice near the center of the lesion and the porta hepatis was repeatedly scanned for 42 s or 41.25 s after intravenous bolus injection of 30~40 ml nonionic contrast media at 4.5~6.7 ml/s. Time-density curve (TDC) of aorta, hepatic artery, portal vein, liver, and spleen were analyzed. The perfusion data such as hepatic arterial perfusion (HAP), portal vein perfusion (PVP), total liver perfusion (TLP), hepatic arterial perfusion index (HAI), and portal vein perfusion index (PVI) were calculated. Pathologic grade and MVD was defined by routine HE and CD34 stain respectively. Results Of the 18 cases, 5 were well-differentiated HCC, 7 moderate, and 6 low. MVD of well-, mid-, and low-differentiated HCC was 73.6, 166.7, and 238.2 per mm2, respectively. The mean perfusion data in turn of HAP, PVP, TLP, HAI, and PVI of the three subgroup were 0.478 ml·min~-1 ·ml~-1 , 0.441 ml·min~-1 ·ml~-1 , 0.918 ml·min~-1 ·ml~-1 , 0.52, 0.48 and 1.216 ml·min~-1 ·ml~-1 , 0.587 ml·min~-1 ·ml~-1 , 1.803 ml·min~-1 ·ml~-1 , 0.67, 0.33 and 1.103 ml·min~-1 ·ml~-1 , 0.473 ml·min~-1 ·ml~-1 , 1.576 ml·min~-1 ·ml~-1 , 0.71, 0.29, respectively. The results showed that well-differentiated HCC had lowest MVD, HAP, PVP, TLP, HAI and highest PVI(P0.01), and mid-differentiated HCC had highest PVP and TLP, while low-differentiated HCC had highest MVD and HAI and lowest PVI(P0.05). Conclusion The perfusion data, especially the perfusion index correlate well with MVD and the pathologic grade of HCC, thus perfusion CT offers a new way to assess the MVD and the pathologic grade of HCC in vivo.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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