Title: Effect Observation on Sitagliptin Combined with Metformin in the Treatment of Incipient and Obese Type 2 Diabetes
Abstract: Objective To investigate the clinical effect of sitagliptin combined with metformin in the treatment of incipient and obese type 2 diabetes. Methods 180 cases of patients with incipient and obese type 2 diabetes treated in our hospital from January 2012 to December 2013 were selected as objects. All the patients were randomly divided into treatment group(92 cases) and control group(88cases). The control group was given glimepiride combined with metformin for treating, while the treatment group received metformin combined with sitagliptin for treating. All the patients were evaluated hepatic and renal function, blood sugar and blood fat, glycosylated hemoglobin, secretion function of islet cell, insulin resistance. The treatment period was 24 weeks. After the treatment, the body weight,fasting blood glucose, postprandial 2 h blood glucose, glycosylated hemoglobin, secretion function of islet cell, insulin resistance of two groups were analyzed and compared. Results The monitoring index(fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, secretion function of islet cell, insulin resistance) of the treatment group was significantly better than the control group, with statistical significant difference(P 0.05). The total effective rate of the treatment group was 92.40%(85/92), significantly higher than72.73%(64/88), with statistical significant difference(P 0.05). The body weight and the incidence of hypoglycemia of the two groups had no statistical significant difference(P 0.05). Conclusions The application of sitagliptin combined with metformin in the treatment of incipient and obese type 2 diabetes can improve the clinical efficacy, significantly relieve adverse effects caused by patients' high blood glucose and increase the effective rate of medication, which is worth promoting.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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