Title: Effect of enalapril and irbesartan on vascular endothelial function in type 2 diabetic patients with atherosclerosis
Abstract: Objective To compare the changes of endothelial function in type 2 diabetic patients with atherosclerosis(AS)after treatment with angiotensin-coverting enzyme inhibitor(ACEI) and angiotensinⅡreceptor blocker(ARB). Methods Totally 144 type 2 diabetic patients with AS were included in this study. The patients were assigned into ACEI group (n=47) with enalapril treatment(starting dose of 2.5 mg/d and graduallyreaching 5 mg/d),ARB group (n=49) with irbesartan treatment(with gradual increase of doses till reaching the maximumdaily dose of 150 mg),and control group(n=48) without the above medication. After a treatment lasting for 3 months, the brachial artery endothelial function was evaluated with two-dimensiona lultrasonography. Results After therapy,endothelium-dependent vasodilation(EDV)of the brachial artery increased from (3.3±2.7)% to(5.6±4.2)% (P=0.001),and endothelium-independent vasodilation(EIV)increased from(12.6±7.4)% to (12.8±7.1)%(P=0.835) in ACEI group. EDV increased from (4.4±2.9)% to (6.2±3.2)% (P=0.038),while EIV decreased from (10.6±5.8)% to (9.5±4.7)% (P=0.230) in ARB group. No statistical changes in the indices were found after therapy in the control group(P0.05).Comparison of endothelial function in the 3 groups showed no statistical significance in the changes of EDV between ACEI and ARB groups(P=0.853).No differences were found in the change of EIV in the 3 groups(P=0.644).Conclusion The therapy with 150 mg irbesartan and 5 mg enalapril for 3 months produces similar effects on the endothelial function in these patients.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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