Title: Exploration on appropriate sedation dose of chloral hydrate for children in ophthalmology department under non-sleep-deprived condition
Abstract: Objective To explore the appropriate dose of chloral hydrate for children in ophthalmology department under non-sleep-deprived condition.Methods One hundred and twenty cases of children,who required sedation for ophthalmologic examination with ASA Ⅰ~ Ⅱ and aged from 1 month to 3 years were chosen.According to their a—ges,the children were divided into the infant group(1~12 months) and children group(1~3 years),who were further randomly divided into 4 groups according to the doses of oral chloral hydrate,the infant group 1 was given 10%0.5 mL/kg chloral hydrate,the infant group 2 was given 10%1 mL/kg chloral hydrate,the children group 1 was given10%0.5 mL/kg chloral hydrate,and the children group 2 was given 10%1 mL/kg chloral hydrate.The sleep latency,bispectral index(BIS) after sleep onset and sedation failure rate were recorded after children took chloral hydrate.During the whole process of sedation,cough reflex,respiratory depression,nausea and vomiting and other adverse reactions in children were recorded.Results Compared with infant group 1,the sleep latency in the infant group 2 was reduced(P 0.05),but the difference in sedation failure rate was not statistically significant(P 0.05).Compared with children group 1,both the sleep latency and sedation failure rate in the children group 2 were reduced(P 0.05).The differences in BIS,various adverse reactions and inspection time between different groups were not statistically significant(P 0.05).Conclusion The appropriate dose of chloral hydrate for infants in ophthalmology department under non-sleep-deprived condition is 0.5 mL/kg,and that for the children is 1 mL/kg.These appropriate doses are associated with satisfactory sedation degree and absence of obvious adverse reactions.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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