Title: Clean procedure for synthesis [4-(4-Aminop-henoxy) (2-pyrid-yl)]-N-methylcarboxamide in ionic liquid
Abstract: [4-(4-Aminophenoxy)(2-pyridyl)]-N-methylcarboxamide is an important intermediate of sorafenib,which can be synthesized via Williamson reactions.The author synthesized the target product from 4-chloro-N-methypiclinamide and 4-Aminophenol via Williamson reaction by use of room-temperature ionic liquid as green solvent,NaOH and K2CO3 as base.Some factors affecting the etherification,such as the type of the ionic liquid,reaction temperature,reaction time and base etc,were studied,and the relatively optimal reaction conditions were worked out: the best solvent is,the molar ratio of reaction are 4-Aminophenol/NaOH = 1/1.1(molar),4-Aminophenol/K2CO3 = 1/0.6(molar),reaction temperature is 75 ℃,reaction time is 4h.Under the above procedures the yield of resulting could be achieved 89%,and the structural confirmation was done by 1H NMR.One additional point should be emphasized that the RIL could be reused at least 5 times without noticeably deteriorating the yield and purity of the product.This is beneficial to environmental protection.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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