Title: Expression and correlation of EGFR and VEGF in cervical carcinoma
Abstract: Objective To study the relationship between the expressions of EGFR, VEGF in cervical carcinoma and to observe the correlation between EGFR and VEGF in them. Methods The expressions of EGFR and VEGF were studied by immunohistochemical EnVision in tissue microarray containing 80 cervical carcinoma tissues and the corresponding adjacent tissues. The relationship between EGFR and VEGF expression and the chinicopathological features was ana- lyzed. Results The positive rates of EGFR and VEGF were 94.8% and 79.1% respectively in cervical carcinoma. How- ever they were 15% and 20% respectively in the corresponding adjacent tissues. Expressions of EGFR and VEGF pro- teins were significantly higher in cervical carcinoma than those in adjacent tissues(P 0.01). The overexpression of EGFR was found significantly associated with the tumer size,tissue type,differentiation degree, knubbly invasive depth, lymphnode metastasis and clinical stage(P0.05). That of VEGF found significantly associated with the tumer size,lym- phnode metastasis and clinical stage(P0.05). Besides, the overexpression of EGFR was correlated with the overexpres- sion of VEGF(r =0.2548, P 0.05). Conclusion The overexpression of EGFR and VEGF in cervical carcinoma are closely correlated with the growth, invasion and metastasis, prognosis, and maybe have synergistic effect in develop- ment of cervical carcinoma.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot