Title: The expression of survivin in normal endometrium and endometrial carcinoma
Abstract: Objective To investigate the expression of survivin in normal endometrium and endometrial carcinoma and its relationship with the clinic features of endometrial carcinoma.To explore the significance of surviving in diagnosis and prognosis of the cancer.Methods The survivin mRNA in 34 endometrial carcinoma and 20 endometrium at secretory or proliferative phase were detected using RT-PCR. Results No significant difference of survivin mRNA was observed between secretory and proliferative phase endometrium. Survivin mRNA expressed more in endometrial carcinoma than in normal endometrium.The expression level of survivin mRNA was closely correlated with clinical stage, histological grade, myometrium invasion in endometrial carcinoma. Conclusion Survivin may be a good diagnostic and prognostic marker of endometrial carcinoma.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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