Title: Comparision of Propafenone and Amiodarone in the Treatment and Prevention of Aroxysmal Artial Fribrillation
Abstract: Objective To investigate the efficacy and safety of propafenone and amiodarone in treating and preventing paroxysmal atrial fibrillation(PAF).Methods 80 patiens with atrial fibrillation were divided into propafenone group(n=32),amiodarone group(n=28) and placebo group(n=20) randomly.Each was treated for more than 3 moths.Results Within 48 hours after treatment the recovery rates in propafenone group,amiodarone group and placebo group were 72.7%,42.1% and 23.1%,respectively.The response rate of propafenone group was higher than that of the other two groups(P0.05).The follow-up period was 21.6±8.0 months,and the total response rates were 62.5%,71.4% and 15.0%,respectively.No significant difference was found between the propafenone group and amiodarone group,but the rate in the two groups was much higher that in the placebo group(P0.01).After more than 12 months' follow-up,the response rate of amiodarone group was superior to the propafenone group(P0.05).The occurrence rates of adverse reactions in the propafenone group and amiodarone group were 18.8% and 17.9% respectively,there was no significant difference(P0.05).No serious side-effects or arrhythmia were found.Conclusion Both drugs were effective and relatively safe in the treatment and prevention of the relapse of PAF.The efficacy of amiodarone is lower in short-term recovery but higher in long-term prevention of recurrence.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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