Title: Detection of serum osteoprotegerin in patients with multiple myeloma and its clinical significance
Abstract: Objective:To investigate the serum osteoprotegerin(OPG) levels in patients with multiple myeloma and the association with bone disease.Method:The levels of serum OPG were detected in both 28 patients with multiple myeloma and 28 controls using ELISA.Result:OPG levels were lower in the patients with multiple myeloma [(222.4±114.8) pg/ml] than those of the controls.OPG levels in patients with 0~1 and 2~3 bone lesions were(312.4 ± 129.6) pg/ml and(179.0 ± 59.4) pg/ml,respectively.This difference was statistically significant(P0.01).OPG levels were not associated with Albumin levels,stage immunologic type,hemoglobin or Calcium levels,but with β2-microglobulin and globulin levels(P0.01).Conclusion:Serum OPG levels were reduced in patients with multiple myeloma and were associated with skeletal destruction.OPG may be used as prognosis factor for patients with multiple myeloma.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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