Title: Change of Cytokin and Its Correlation to Cardiac Function after Reperfusion from Different Duration of Prolonged Cardiopulmonary Bypsaa (CPB)and Aortic Cross-Clamp
Abstract: Objective:To explore the change of cytokin and its correlation to cardiac function after reperfusion from different duratices of prolonged CPB and aortic cross-clamp.Methods:Twelve male mongrel wolf dogs under CPB were randomly divided into two groups,groupⅠ(n=6),aortic cross-clamp for 25 min and group Ⅱ(n=6),aortic cross-clamp for 150 min.Tumor necrosis factor-alpha(TNF-α)and interleukin 6(IL-6)in the arterial blood were detected at pre-bypass and 180min after reperfusion,respectively.Hemodynamics were detected at pre-bypass,180min after reperfusion,respectively.Results:At 180min after reperfusion,the levels of TNF-α and IL-6 were increased significantly as compared with those of the pre-bypass in groupⅠ(P0.05),but were increased markedly in groupⅡ(P0.05),and the difference between two groups was significant(P0.05).The MBP,CI,SVI and LVSVWI renained unchanged as compared with those of pre-bypass in groupⅠ(P0.05),but siginficantly decreased in group Ⅱ,and there was significant difference between the two groups at 180min after reperfusion (P0.05).The levels of TNF-α and IL-6 were negatively correlated to the MBP,CI,SVI and LVSWI.Conclusion:Prolonged CPB and aortic cross-clamp were the primary causes resulting in the increase of cytokin.The level of cytokin was negatively correlated to cardiac function after myocardial ischemia reperfusion during CPB.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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