Title: Reducing obesity and regulating serum lipid of tea polyphenols on obesity rats induced by olanzapine
Abstract: OBJECTIVE To investigate the reducing obesity and regulating serum lipid of tea polyphenols on obesity rats induced by olanzapine.METHODS Female SD rats were randomLy divided into normal congtrol group(10rats)and obesity model group(40rats)which was given olanzapine(1.2mg·kg-1,q.d.)via gavage 1 h before the beginning of the dark-phase.Body weight and amount of food and water were measured each 2 days.Then obesity rats were randomLy divided into model group(9 rats),sibutramine group(2.5mg·kg-1,8 rats),tea polyphenols high(300mg·kg-1,8 rats)and low(150mg·kg-1,8 rats)groups.These drugs and Olanzapine(1.2mg·kg-1,q.d.)were administered to rats for 5 weeks by intragastric administration.During drugs treatment,body weight were measured each time one week and amount of food and water were detected twice one week.Serum lipid(TC,TG,HDL-C,LDL-C,FFA)was measured at experimental end.RESULTS After tea polyphenols treatment for 5 weeks,food intake,water drinking and body weight were significantly lower than those of model group(P0.05 or P0.01); Lee’s index,fat weight and coefficient of fat were significantly lower than those of model group too(P0.05 or P0.01); the contents of LDL-C and FFA were reduced significantly(P0.05 or P0.01),and the levels of TC and TG were decreased too.CONCLUSION Tea polyphenols can reduce body weight,inhibiting obesity and tegulating serum lipid in obesity rats induced by olanzapine.These effects may be concerned with inhibiting food intake and water drinking,increasing animal spontaneous activity.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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