Title: Function of B Cells in Patients with Primary Sjgren’s Syndrome
Abstract: Primary Sjgren’s syndrome(pSS) is an autoimmune disorder characterized by specific pathological features.One of these hallmarks is abnormal changes of B cells.Recent researches,including cytokines such as chemokines,immunoglobulin genes and mRNA transcripts,and autoantibody responses,found disturbed differentiation and selection of B cell.Highly expressed B cells leading to the large number of abnormal autoantibodies and hypergammaglobulinemia in the peripheral blood.The changes in the distribution of peripheral B-cell subsets and B-cell selective infiltration in the tissue like exocrine glands forming lymphoid tissues may possibly be related to a lack of appropriate censoring mechanisms within the ectopic lymphoid structures of the inflamed tissues.Although this mechanism remains unclear,this summary of the B-cell functions in primary Sjgren’s syndrome from above findings may add to the understanding of the pathogenesis of this autoimmune inflammatory disorder and may result in new therapeutic approaches.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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