Title: Inducing ureteral contractile response using KCl and its application
Abstract: Objectives: To induce contraction of ureteral smooth muscle using high concentration potassium chloride (KCl) and assess its value in determining the ureteral contractibility. Methods: Six normal and 6 treated rabbits were involved in the experiment. Their ureteral segments were removed and suspended in an organ bath filled with fresh Krebs solution for measurement of isometric contractile force. The Krebs solution was bubbled with a mixture of 95% O 2 and 5% CO 2 . All samples were stimulated with KCl, and the contractile activity was recorded on a polygraph. Results: Ninety four mmol/L of KCl could induce contractile response in both normal and treated ureters. Most contractions consisted of 2 phases: first a slow, tonic contraction superimposed upon a burst of phasic contractions. The contractility of the treated ureters was significantly reduced ( P 0.05) compared to normal. Conclusions: High concentration of KCl could efficiently induce contractile response in the isolated rabbit ureteral segment. This method may be used to determine the function of ureteral smooth muscle.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot