Title: Determination and clinical significance of matrix metalloproteinase-9 in children with henoch-schonlein purpura
Abstract: Objective To investigate the role of serum matrix metalloproteinase-9 in children with henoch-schonlein purpura. Methods The serum concentration of MMP-9 was measured by enzyme-linked immunosorbent assay method in 40 acute SHP patients, 35 recovery patients and 30 healthy controls. Results The serum levels of MMP-9 and C-reactive protein in acute phase were significantly higher than those in healthy controls and those during recovery period(t=12.30,8.42,6.37,8.13,P 0.05). The serum level of MMP-9 in the HSP patients dropped back slowly and their levels during recovery period was still higher than those in healthy controls (t=9.92,P0.05). The serum levels of MMP-9 were higher in renal damage and gastrointestinal symptoms groups than those in non-renal damage and non-gastrointestinal symptoms groups (t=3.75,3.17,P0.05), whereas the serum level of CRP had no significant difference between them (t=0.96,0.56,P0.05). The serum level of MMP-9 showed positive correlation with the level of CRP(r=0.68, P0.05). Conclusions The damage of extracellularmatrix plays an important role in the pathological mechanism of HSP. The level of MMP-9 may be used as index of the HSP activity and progression as well as the damage of gastrointestinal and renal system in HSP.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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