Title: Effect of dexmedetomidine on the analgesic effect of postoperative patient-controlled epidural analgegia using ropivacaine and pentazocine
Abstract: Objective To investigate the effect of dexmedetomidine on the analgesic effect of postoperative patient-controlled epidural analgegia (PCEA) using 0.1% pentazocine and 0.2% ropivacaine after transabdominal hys-terectomy. Methods One hundred and twenty patients undergoing transabdominal hysterectomy were divided ran-domly into three groups: group P1, P2, P3 (n=40). Patients in the three groups all received postoperative patient-controlled epidural analgegia (PCEA) using 0.1% pentazocine added to 0.2% ropivacaine. The model of PCA was LCP with loading dose (LD, dexmedetomidine 0.5 μg/kg or Physiological saline) 5 ml+ continue infusion dose (CI) 1 ml+ bolus dose 3 ml in group P1 or P3, and that with LD (Physiological saline) 5 ml+CI 2 ml+bolus dose 2 ml in group P2. The total dosage of ropivacaine and pentazocine, the duration of motor block, VAS score of wound pain 1 h, 2 h, 4 h, 8 h, 16 h, 24 h after PCA pump and adverse effects were recorded. Results The total dosage of ropivacaine and pentazo-cine in group P3 was significantly lesser than group P1 (P0.05). Duration time of motor block with Group P3 was significantly shorter and incidence of shiver was significantly lower than those in Group P1 (P0.05). VAS of wound pain in group P2, P3 was lower than that in group P1 (P0.05), while that in group P2, P3 showed no statistically significant difference (P0.05). Conclusion Dexmedetomidine 0.5 μg/kg given by epidural injection improves the quality and the duration of postoperative analgesia, and also provides an analgesic sparing effect in patients undergoing transabdominal hysterectomy.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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