Title: Expression of Bag-1,BcL-2 and PCNA in gastric carcinoma tissue
Abstract: Objective: To detect the expression of Bag-1,BcL-2 and PCNA in gastric carcinoma tissue and to explore the relationship between Bag-1 and the two others.Methods: The expression of Bag-1,BcL-2 and PCNA of the tissues of 60 patients with gastric carcinoma and 10 normal controls were assayed by the immunohistochemical method.Results: The expression rate of Bag-1,BcL-2 and PCNA was 58.3%,46.7% and 83.3%,respectively,with a significant difference compared with the normal control ones.The BcL-2 expression was correlated with the pathologic type and gastric tissue grading.The PCNA expression was significantly related to the gastric carcinoma staging and infiltration degree.The Bag-1 expression was directly correlated with The BcL-2 expression(r=0.4518,(P0.05)).Conclusion: Bag-1 and BcL-2 can be used as indexes in the early diagnosis of gastric carcinoma.The simultaneous detection of the expression of Bag-1,BcL-2 and PCNA is helpful for the early diagnosis and pathologic type and histology staging of gastric carcinoma.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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