Title: Progress in research on ICCs in gastrointestinal tract and SCF/c-kit signal system
Abstract: Gastrointestinal interstitial cells of Cajal(ICCs),distributed throughout the whole gastrointestinal(GI) tract,are a special kind of mesenchymal cells.The special relationship among ICCs,enteric nervous system and smooth contributes to the formation of the neuron-ICC-smooth muscle networks.Especially,ICC is the important coordinator in the network,and is closely related with the generation of intestinal slow waves.There is the signaling pathway which is activated by ckit,a specific membrane receptor of ICC,binds to stem cell factor(SCF),a ligand for c-kit,and the pathway plays an important role in the development and maintenance of ICC.Therefore,through the investigation of the SCF/c-kit signaling pathway,it is expected to find a new therapy for ICCs associated gastrointestinal motility disorders.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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