Title: Application of diffusion and perfusion weighted imaging in the ischemic penumbra of the hyperacute infarct
Abstract: 【Objective】 To explore the ischemic penumbra of the hyperacute infarct by diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI),trying to raise the quantitative evaluation standards.【Methods】MRI was performed in 13 patients with clinically diagnosed hyperacute infarct from 2h to 6h after the onset of symptoms,including DWI and PWI.All the patients were followed up by T2WI image to determine the final infarct area within 2 to 28 days.Diffusion and perfusion changes were measured in the infarct area,ischemic penumbra and control area.【Results】 ①The average value of apparent diffusion coefficient (ADC) in the infarct center was 7.01×10-4 mm2/s and that of rADC was 0.63,as for the ischemic penumbra,the average value of ADC was 9.36 ×10-4 mm2/s,and that of rADC was 0.87.The difference was significant.② PWI demonstrated the regional cerebral blood reduction or absence in 11 patients.However,in two patients with lacunar cerebral infarct,PWI was normal.③If PWIDWI,the area with slightly decreased ADC value (22%) might be the ischemic penumbra,while the area with obviously decreased ADC(25%~53%) was irreversible infarct area.【Conclusion】 DWI combined with PWI can diagnose the hyperacute infarct and evaluate the change of ischemic penumbra.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot