Title: Electrophysiological Effects of Sea Anemone Toxins
Abstract: Sea anemone toxins are polypeptide toxins extracted from marine invertebrates-sea anemones.There are many kinds of sea anemone toxins,including anemone sulcata toxins(ATX) extracted from Anemona sulcata,actinia equina toxins(EqT) from Actinia equina,anthopleurin toxins(AP) from Anthopleura xanthogrammica and so on.The toxins mainly acted as cardiac stimulators and neurotoxins.Most toxins are known to bind selectively to sodium channels in neuronal cells,cardiac myocytes and skeletal muscles,and prolong the time course of sodium current(INa) by slowing channel inactivation with little or no effect on activation.They had different affinities to sodium channels in different tissues or to different channel subtypes.Some sea anemone toxins could block potassium channels.The toxins were mainly used as tools to research the structure and function of ion channels.Some sea anemone toxins also had other effects such as antiviral activity,cytotoxicity and so on.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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