Title: Synthesis of N,N-dimethyl-3-chloropropylamine Hydrochloride by Phase Transfer Catalysis
Abstract: PEG 600 was used as phase- transfer catalyst to synthesize N,N- dimethyl- 3- chloropropylamine Hydrochloride from dimethyl amine and 1- bromo- 3- chloropropane. The effects of factors,such as the concentration of the catalyst of PEG 600,the mole ratio of dimethyl amine to 1- bromo- 3- chloropropane,the reaction temperature and the reaction time on the yield,were examined. The optimal reaction conditions were determined as follows: the mole ratio of dimethyl amine to 1- bromo- 3- chloropropane was 1. 2,PEG 600 catalyst was 2. 0 g,the reaction time was 4 h,the reaction temperature was 35 ~ 40 ℃,and the yield reached 73. 7%.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot