Title: Effects of sevoflurane preconditioning on inflammatory cytokine and myocardial enzyme in patients undergoing cardiac valve replacement
Abstract: Objective It is to investigate the effect of sevoflurane( Sev) preconditioning on inflammatory cytokine and cardiac enzyme in the patients undergoing cardiac value replacement( CVR) and to explore the mechanism of Sev protecting heart. Methods A total of 60 ASA Ⅱ- Ⅲ patients under cardiopulmonary bypass for CVR,were randomly assigned into 2groups( n = 30) : control group( group C) and Sev preconditioning group( group S). Group S received 1. 0% Sev after anesthesia induction lasting for 30 min,and then being washed out until the beginning of CPB when the end tidal concentration of Sev was lower than 0. 1%. Anesthesia was maintained with propofol,midazolam,sufentanil and vecuronium,BIS was maintained at 40- 50. Group C received the same treatment as group S but no Sev preconditioning. The artery blood samples were collected to detect the serum concentration of IL- 6,IL- 8,TNF- α and the plasma levels of c Tn I,CK and CK- MB before anesthesia( t0),at the time of aortic unclamping( t1),2 h( t2) after aortic unclamping and 24 h( t3) after operation,respectively. Results The serum concentration of IL- 6,IL- 8 and TNF- α were higher at t2 and t3in both groups than at t0 and t1respectively( P 0. 05),they were decreased at t3 in both groups than at t2( P 0. 05),they were significantly lower at t2 and t3in group S than in group C( P 0. 05). Plasma levels of c Tn I,CK and CK- MB were within normal range at t0 in two groups,compared with t0,those in the two groups were increased significantly at t1- t3( P 0. 05),compared with the group C,they were significantly lower in the group S at t1- t3. Conclusion Sev preconditioning could alleviate the ischemia / reperfusion injury in patients undergoing CVR,which may be related to the inhibition of inflammatory factors and the reducing of myocardial enzyme.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot