Title: Protective effect of Hydroxyethyl starch against myocardial ischemia-reperfusion injury in rats
Abstract: Objective To observe the protective effect of hydroxyethyl starch 130/0.4(HES130/0.4) against myocardial ischemia-reperfusion(I/R) injury in rats.Methods Forty-six SD rats were randomly divided into four groups: sham operation group(S),ischemia-reperfusion group(IR,treated with 7.5 ml/kg saline),albumin-ischemia-reperfusion group(A-IR,treated with 7.5 ml/kg 5% albumin) and HES-ischemia-reperfusion group(V-IR,treated with 7.5 ml/kg HES130/0.4) via jugular vein at ischemia 25 min.HR,MAP,LVSP and ±dp/dtmax were recorded at ischemia 30 min,reperfusion 60,120 and 180 min.Myocardial infarct size was determined by 2,3,5-triphenyltetrazolium chloride(TTC) staining method.The changes of activity of MPO and histopathology were examined.Results At ischemia 30 min,reperfusion 60,120 and 180 min,V-IR group significantly increased HR,MAP,LVSP and ±dp/dtmax compared with group IR and A-IR(P0.05).Myocardial infarct size in V-IR group was significantly smaller as compared with group IR and A-IR(P0.05).The activity of MPO was increased significantly in the IR,A-IR and V-IR groups compared with S group(P0.05),which was decreased significantly in V-IR group compared with that in the IR and A-IR groups(P0.05).Histological examination showed that the degree of injury in group V-IR was significantly ameliorated compared with that in group IR and A-IR.Conclusion HES130/0.4 could improve myocardial function and attenuate ischemia-reperfusion injury,and the mechanism may be inhibition of the infiltration of polymorphonuclear neutrophils.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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