Title: Pathologic diagnosis of non-Hodgkin lymphoma with bone marrow involvement:an analysis of 41 cases
Abstract: Objective To explore the value of pathology at the diagnosis of non-Hodgkin lymphoma(NHL) involvement in the bone marrow.Methods Routine histologic examination was performed on bone marrow biopsies.Immunophenotype study was conducted on flow cytometric(FC) and immunohistochemical(IHC)methods.Results Among 41 NHLs,27 were B lymphomas and 14 were T types.The frequency of patterns of NHL bone marrow infiltration was as follow:diffuse(15/41,36.59%),mixed(11/41,26.83%),interstitial(9/41,21.95%),nodular(5/41,12.20%)and intrasinusodial(1/41,2.44%).Combined FC and IHC method,all of the 41 specimens could be immunophenotyped.37(37/41,90.24%) cases were immunophenotyped by FC alone,others based on extramedullary pathologic findings and bone marrow IHC result.12 of 15 cases could be phenotyped with IHC method,other 3(2 were SLL/CLL,and 1 HCL) cases should be combined with FC analysis.1 case of DLBCL could be phenotyped by IHC whereas FC could not.Conclusion Both bone marrow morphology and immunophenotype are of important significance at the diagnosis of NHL bone marrow involvement.FC and IHC are complementarity at immunophenotype.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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