Title: Synthesis of ibuprofen ester prodrug and its hydrolysis kinetics
Abstract: Objective To synthesize ibuprofen eugenol ester and study its hydrolysis kinetics.Methods Ibuprofen eugenol ester was synthesized by acylation reaction using ibuprofen and eugenol as the starting materials.The kinetics of ester hydrolysis was studied in aqueous buffer solutions pH 1.10-10.91 as well as rat plasma and rat liver homogenate by the HPLC method.Results The structure of ibuprofen eugenol ester was confirmed by IR,UV,MS and(()~1H)NMR spectroscopy and its purity was established by HPLC.The ester was stable at a wide pH range form 1.10 to 9.96.However,it was hydrolyzed by enzymes from 80% rat plasma and rat liver homogenate to form ibuprofen and eugenol.Conclusions Ibuprofen eugenol ester is a promise prodrug of non-steroidal anti-inflammatory drugs(NSAIDs).
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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