Title: Study of Acute and Long-term Toxicity of Xiaoerzhike Granules
Abstract: Objective To study the acute and long-term toxicity of Xiaoerzhike granules.Methods the maximum tolerance dose(MTD)on mice was used to detect the acute toxicity.Xiaoerzhike granules in high,medium and low dosages were given continuously to rats for 90 days in long-term toxicity trial to observe on behavior,blood cytology indexes,blood biochemical indicators,organ indexes,systemic anatomy examination and reversibility observation.Results no obvious indication of toxic symptom was observed in mice in the acute toxicity trial.The results of long-term toxicity trial indicate that there was no significant difference in appearances,behaviors and activities,body weights,blood cytology indexes,blood biochemical indexes,organ indexes and systemic anatomy examination in the rats of the three groups of high,medium and low dosages.The reversibility study demonstrates that there was no delayed toxicity caused in the rats of three dosage groups as compared to control group.Conclusion Xiaoerzhike granules have no significant toxic effect on substantial organs shown in the acute and long-term toxicity trials conducted on mice and rats,and may be provided for clinical applications.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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