Title: The research on the clinical application of tumor markers combined detection in the early diagnosis of gastric cancer
Abstract: Objective To observe and analyze the clinical application effects of the combined detection of serum tumor markers of carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),CA242,CA724in the early diagnosis of gastric cancer.Methods 80cases of gastric cancer patients were selected as the observation group.50cases of the patients with chronic atrophic gastritis complicated with severe atypical hyperplasia at the same period were selected as the CAGD group.50cases with normal gastric mucosa or superficial gastritis at the same period were selected as the control group.The serum tumor marker of CEA,CA199,CA242,CA724levels of the objects in the three groups were detected and compared.Results The serum CA199,CA242,CA724,CEA levels of the patients in the observation group were significantly higher than those of the CAGD group(P0.05),and the serum tumor markers of the patients in the CAGD group were significantly higher than those of the control group(P0.05);the serum CA199,CA242,CA724positive rates of the patients with low tumor differentiation were significantly higher than those of high or medium differentiation of tumor patients(P0.05);the serum CA199,CA242,CA724,CEA positive rates of the patients with liver metastasis were higher than those of the patients without metastasis(P0.05);the serum CA199,CA242,CA724,CEA positive rates of the patients at clinical stage III or IV stage were significantly higher than those of the patients at clinical stageⅠ-Ⅱpatients(P0.05);when 4serum tumor markers joint detection was applied,the sensitivity and specificity was 85% and 92.5%,the sensitivity was significantly higher than that when 3,2or single serum tumor markers were detected(P0.05)and the difference of specificity was not significant when 2or single serum tumor markers were detected(P0.05).Conclusion the abnormal increasing of the serum tumor markers of CA199,CA242,CA724,CEA may indicate the occurrence of gastric precancerous lesions or early tumor and can be used as the auxiliary indexes in the early diagnosis of gastric cancer.The positive detection rate of the tumor markers detection is correlated with the progression of the disease and can be used to predict the disease progression and the prognosis of patients.The application of the combined detection of the 4serum tumor markers in the early diagnosis of gastric cancer can improve the sensitivity of the diagnosis.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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