Title: P21 and P53 protein expression in intestinal metaplasia and dysplasia of gastric mucosa
Abstract: IM To study the relationship between intestinal metaplasia or dysplasia of gastric mucosa and gastric cancer. METHODS P21 and P53 protein expressions were determined in 58 formalinfixed, paraffinembedded specimens of intestinal metaplasia (n=44) and dysplasia of gastric mucosa (n=14) by the SP immunohistochemical method. RESULTS The positive rates of P21 and P53 proteins in type Ⅱb intestinal metaplasia (IM) (700% and 300%) were statistically higher than those in type Ⅰb IM (258% and 64%,P001). The positive rates of P21 and P53 proteins in dysplasia (428% and 285%) were higher than those in IM (34% and 118%). The positive rates of P21 and P53 proteins in dysplasia with type Ⅱb IM (625% and 375%) were significantly higher than those in dysplasia with type Ⅰb IM (166% and 166%).CONCLUSION Dysplasia accompanied by type Ⅱb IM may more easily develop gastric cancer than other lesions.
Publication Year: 1997
Publication Date: 1997-01-01
Language: en
Type: article
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Cited By Count: 3
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