Title: The change of cholinergic neurons of hippocampus and praxio logy in vascular dementia rats
Abstract:Objective To study the change of cho li nergic neurons of hippocampus and praxiology of vascular dementia rats. Methods The rats were divided into control and operation group rando mly. The vascular d...Objective To study the change of cho li nergic neurons of hippocampus and praxiology of vascular dementia rats. Methods The rats were divided into control and operation group rando mly. The vascular dementia model was reproduced. After 30 days, abilities of lea rning and memory of two group rats were tested by using the Morris water maze. I mmunochemistry staining was used to observe the number of cholinergic neurons of CA1 subfield of hippocampus. Results The number of the ChAT positive neurons in the CA1 subfield of the hippocampus in control and operation group was 119.15±2.02 and 39.96±3.16 respectively. Abilities of learning and memory of rats and the number of the ChAT positive neurons in the CA1 subfie ld of the hippocampus were more significantly decreased in operation group (P 0.01 or P0.01). Conclusion The number of cholinergi c neurons and abilities of learning and memory of vascular dementia rats are dec reased.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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