Title: Effects of Aminosalicylic Acid on Peak Blood Concentration of Rifampicin
Abstract:OBJECTIVE:To investigate the effects of aminosalicylic acid on peak blood concentration of rifampicin in pulmonary tuberculosis patients receiving Isoniazid aminosalicylate tablets.METHODS:Taking the ...OBJECTIVE:To investigate the effects of aminosalicylic acid on peak blood concentration of rifampicin in pulmonary tuberculosis patients receiving Isoniazid aminosalicylate tablets.METHODS:Taking the same patients before-after controlled method,observation group received Isoniazid aminosalicylate tablets and Rifampicin capsules,and control group received Isoniazid tablets and Rifampicin capsules.The peak blood concentrations of isoniazid and rifampicin were detected in 2 groups.The effects of Isoniazid aminosalicylate tablets on peak blood concentration of rifampicin were observed.RESULTS:The mean blood concentrations of isoniazid and rifampicin after taking drugs for 1.5 hours were(4.88±2.32)μg·mL-1 and(6.49±3.40)μg·mL-1 in control group,(2.62±2.34)μg·mL-1 and(5.84±2.74)μg·mL-1 in observation group.There was no significant difference in peak blood concentration of rifampicin between two groups(P0.05),and there was significant difference in peak blood concentration of isoniazid between two groups(P0.05).CONCLUSION:Aminosalicylic acid of Isoniazid aminosalicylate tablets has no obvious effect on peak blood concentration of rifampicin.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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